Article

Variant load of Mitochondrial DNA in single human Mesenchymal stem cells

2023-12-21

Abstract excerpt

Mesenchymal stem cells (MSCs) are the parent cells to many cells of the musculoskeletal system including osteoblasts. Previous work has shown that in mouse models mitochondrial DNA (mtDNA) pathological variants lead to dysfunction of the respiratory chain of these osteoblasts and the premature development of age related osteoporosis. An increased rate of respiratory chain deficiency has also been observed in human...

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Literature Corpus work: 7f7190ee-d3d8-51c6-b186-c3906ab3e417
DOI: 10.21203/rs.3.rs-3735071/v1

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