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Article

Variant load of mitochondrial DNA in single human mesenchymal stem cells.

Scientific reports - 9 Sept 2024

Hipps Daniel, Pyle Angela, Porter Anna L R, Dobson Philip F, Tuppen Helen, Lawless Conor, Russell Oliver M, Turnbull Doug M, Deehan David J, Hudson Gavin

Abstract excerpt

Heteroplasmic mitochondrial DNA (mtDNA) variants accumulate as humans age, particularly in the stem-cell compartments, and are an important contributor to age-related disease. Mitochondrial dysfunction has been observed in osteoporosis and somatic mtDNA pathogenic variants have been observed in animal models of osteoporosis. However, this has never been assessed in the relevant human tissue. Mesenchymal stem...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39251776
DOI: 10.1038/s41598-024-71822-4
PMCID: PMC11385243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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