Article

Detecting respiratory chain deficiency in osteoblasts of older patients

2021-10-07

Abstract excerpt

Mitochondria contain their own genome which encodes 13 essential mitochondrial proteins and accumulates somatic variants at up to 10 times the rate of the nuclear genome. These mitochondrial genome variants lead to respiratory chain deficiency and cellular dysfunction. Work with the PolgAmut/PolgAmut mouse model, which has a high mitochondrial DNA mutation rate, showed enhanced levels of age related osteoporosis i...

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Literature Corpus work: 8b0e0ce0-06f6-5166-8b0e-b5a617ab726c
DOI: 10.1101/2021.10.06.21264231

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