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Article

Mitochondrial DNA sequence variation in single cells from leukemia patients.

Blood - 15 Jan 2007

Yao Yong-Gang, Ogasawara Yoji, Kajigaya Sachiko, Molldrem Jeffrey J, Falcão Roberto P, Pintão Maria-Carolina, McCoy J Philip, Rizzatti Edgar Gil, Young Neal S

Abstract excerpt

A high frequency of mtDNA somatic mutation has been observed in many tumors as well as in aging tissues. In this study, we analyzed the mtDNA control region sequence variation in 3534 single normal cells and individual blasts from 18 patients with leukemia and 10 healthy donors, to address the mu...

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Share to Cell Nucleus
Share to DNA, Mitochondrial
Share to Leukemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Point Mutation

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Sensitivity and Specificity

Share to Sequence Analysis, DNA

Share to Sequence Deletion

Source

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Identifiers

PMID: 16946307
DOI: 10.1182/blood-2006-01-011007
PMCID: PMC1785100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16946307-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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