Article

Characterization of the Mitochondrial Genome Landscape in MSCs, iPSCs and iMSCs from Osteoarthritis Patients and Healthy Donors

2026-06-26

Abstract excerpt

<h4>Background: </h4> /Objectives: Osteoarthritis (OA) is strongly associated with mitochondrial dysfunction, oxidative stress, and the accumulation of mitochondrial DNA (mtDNA) alterations, which contribute to impaired cellular homeostasis and reduced regenerative potential. In this study, we systematically characterized mtDNA heteroplasmy and variant distribution across bone marrow-derived mesenchymal stromal ce...

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Literature Corpus work: 8ae0e8b8-892f-5d36-b912-08fe5c00e4b6
DOI: 10.20944/preprints202606.1975.v1

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