Article

Nicastrin as a novel therapeutic target in breast cancer

2011-01-01

Abstract excerpt

Nicastrin is an essential component of the gamma-secretase (GS) enzyme complex, required for its synthesis and recognition of substrates for proteolytic cleavage. The purpose of this study was to investigate whether nicastrin has a prognostic value or the potential as a therapeutic target in breast cancer. Tissue microarrays (TMAs) (n = 1050), and breast cancer cell line analyses confirmed that nicastrin expressio...

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Literature Corpus work: 7f5cd0e2-a169-5bbd-9462-8f3a9b1bb183
DOI: 10.25560/14694

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