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Article

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.

The Journal of biological chemistry - 29 Aug 2003

Li Jinhe, Fici Gregory J, Mao Chai-An, Myers Richard L, Shuang Rongqing, Donoho Gregory P, Pauley Adele M, Himes Carol S, Qin Wenning, Kola Ismail, Merchant Kalpana M, Nye Jeffrey S

Abstract excerpt

Nicastrin is a component of the gamma-secretase complex that has been shown to adhere to presenilin-1 (PS1), Notch, and APP. Here we demonstrate that Nicastrin-deficient mice showed a phenotype that is indistinguishable from PS1/PS2 double knock-out mice, whereas heterozygotes were healthy and viable. Fibroblasts derived from Nicastrin-deficient embryos were unable to generate amyloid beta-peptide and failed to...

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Identifiers

PMID: 12815056
DOI: 10.1074/jbc.M301288200

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.PMID 12815056Read ↗

Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.Semantic proximity Read ↗

Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.Semantic proximity Read ↗

Drosophila nicastrin is essential for the intramembranous cleavage of notch.Semantic proximity Read ↗

Nicastrin binds to membrane-tethered Notch.Semantic proximity Read ↗

Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model.Semantic proximity Read ↗

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.Semantic proximity Read ↗

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.Semantic proximity Read ↗

Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.Semantic proximity Read ↗

Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.Semantic proximity Read ↗

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.Semantic proximity Read ↗

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain.Semantic proximity Read ↗

The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein.Semantic proximity Read ↗

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