Article
Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Apr 2003
Li Tong, Ma Guojun, Cai Huaibin, Price Donald L, Wong Philip C
Abstract excerpt
Recent studies indicate that nicastrin (NCT) and presenilins form functional components of a multimeric gamma-secretase complex required for the regulated intramembraneous proteolysis of Notch and beta-amyloid (Abeta) precursor protein (APP). To determine whether nicastrin is required for proteolytic processing of Notch and APP in mammals and the role of nicastrin in presenilin/gamma-secretase complex assembly,...
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