Article

Evaluation of drug resistance markers in breast cancers : roles in stemness and epithelial-to-mesenchymal transitions

2016-01-01

Abstract excerpt

There is an urgent need to identify markers of diagnostic and prognostic significance that can help in the development of novel cancer therapeutics. The principal aim of the present study was to evaluate nicastrin and EP300 as potential markers associated with breast cancer drug resistance. Nicastrin is a component of γ-secretase, an intermembrane complex of four proteins with roles in proliferation, cell adhesion...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 33c962ab-9367-567d-8f2d-320f272cdb27
DOI: 10.25560/55256

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evaluation of drug resistance markers in breast cancers : roles in stemness and epithelial-to-mesenchymal transitionsDOI 10.25560/55256Read

Nicastrin as a novel therapeutic target in breast cancerSemantic proximity Read

A combined approach on the impact of EP300 overexpression on drug resistance, invasion and stemness in breast cancerSemantic proximity Read

Molecular characterization of the residual disease after neoadjuvant endocrine therapy in ER+/HER2- breast cancer uncovers biomarkers of tumour responseSemantic proximity Read

EP300 Knockdown Reduces Cancer Stem Cell Phenotype, Tumor Growth and Metastasis in Triple Negative Breast CancerSemantic proximity Read

ERM proteins in cancer progressionSemantic proximity Read

Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention.Semantic proximity Read

ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancerSemantic proximity Read

EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer.Semantic proximity Read

Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapySemantic proximity Read

ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancerSemantic proximity Read

Calreticulin mediates an invasive breast cancer phenotype through the transcriptional dysregulation of p53 and MAPK pathwaysSemantic proximity Read

Eplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcomeSemantic proximity Read