Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through the Notch and phosphoinositide 3-kinase/AKT signalling pathways.

Abstract excerpt

BACKGROUND: Acne inversa (AI) is a chronic inflammatory skin disease with an autosomal dominant inheritance pattern. Mutations of the gene encoding nicastrin (NCSTN), a cofactor subunit of γ-secretase, are responsible for familial AI. However, whether deficiency of nicastrin is functionally implicated in the biological behaviours of human keratinocytes and related molecular mechanisms remains unknown. OBJECTIVES:...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amyloid Precursor Protein Secretases
• Share to Gene Knockdown Techniques