Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rat nicastrin gene: cDNA isolation, mRNA variants and expression pattern analysis.

Brain research. Molecular brain research - 20 May 2005

Confaloni Annamaria, Crestini Alessio, Albani Diego, Piscopo Paola, Campeggi Lorenzo Malvezzi, Terreni Liana, Tartaglia Marco, Forloni Gianluigi

Abstract excerpt

Nicastrin is a type 1 transmembrane glycoprotein that interacts with presenilin, Aph-1, and Pen-2 proteins to form a high molecular complex with gamma secretase activity. Then, nicastrin has a central role in presenilin-mediated processing of beta-amyloid precursor protein and in some aspects of Notch/glp-1 signaling in vivo. Here, we isolated a rat nicastrin cDNA and investigated gene expression in embryonic and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid Precursor Protein Secretases
Share to Blotting, Northern

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebral Cortex

Share to Cycloheximide

Share to Embryo, Mammalian

Share to Neuroblastoma

Share to Neuroglia

Share to Protein Synthesis Inhibitors

Source

Identifiers

PMID: 15893582
DOI: 10.1016/j.molbrainres.2004.12.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rat nicastrin gene: cDNA isolation, mRNA variants and expression pattern analysis.PMID 15893582Read ↗

A novel alternative splice variant of nicastrin and its implication in Alzheimer disease.Semantic proximity Read ↗

Identification and characterization of a novel human APH-1b splice variant lacking exon 4.Semantic proximity Read ↗

Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.Semantic proximity Read ↗

Wild-type and mutated nicastrins do not display aminopeptidase M- and B-like activities.Semantic proximity Read ↗

The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein.Semantic proximity Read ↗

Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.Semantic proximity Read ↗

The presenilins.Semantic proximity Read ↗

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.Semantic proximity Read ↗

Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.Semantic proximity Read ↗

BACE1 Dependent Neuregulin Processing: ReviewSemantic proximity Read ↗

Aph-2/NicastrinSemantic proximity Read ↗

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.