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Article

Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.

Brain research - 1 May 2006

Nguyen Van, Hawkins Cynthia, Bergeron Catherine, Supala Agnes, Huang Jean, Westaway David, St George-Hyslop Peter, Rozmahel Richard

Abstract excerpt

Nicastrin is a member of the high molecular weight presenilin complex that plays a central role in gamma-secretase cleavage of numerous type-1 membrane-associated proteins required for cell signaling, proliferation and lineage development. We have generated a nicastrin-null mouse line by disrupti...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16626651
DOI: 10.1016/j.brainres.2006.02.122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16626651-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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