Article

Transferable Transcriptional Topic Modeling Traces Medulloblastoma Subtypes to Distinct Cerebellar Developmental States

2025-11-13

Abstract excerpt

<h4>SUMMARY</h4> Single-cell transcriptomics transformed our understanding of cellular heterogeneity, yet cross-dataset comparison remains fundamentally limited by batch effects, technology differences, and inconsistent annotation frameworks. These challenges have impeded efforts to connect developmental programs with disease states which creates a critical gap for understanding pediatric cancers with suspected d...

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Literature Corpus work: 7f413f0b-6a81-5e00-90f1-8714bb8bc2d6
DOI: 10.1101/2025.11.12.687706

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