Article

TopicVI: A Knowledge-guided deep interpretable model for resolving context-specific gene programs

2026-04-10

Abstract excerpt

Mechanistic insights from single-cell and spatial transcriptomics largely rely on cell clustering, differential expression analysis, and interpretation through prior biological knowledge. However, this approach is often limited by the reliance on curated biological priors that fail to capture context-specific gene programs, particularly in complex disease states. To address this gap, we introduce TopicVI, a deep i...

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Literature Corpus work: 995b37f7-020b-52e6-afba-b751d7a6be5b
DOI: 10.64898/2026.04.08.717220

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