Article

Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology

2024-10-22

Abstract excerpt

Medulloblastoma and ependymoma are common pediatric central nervous system tumors with significant molecular and clinical heterogeneity. We collected bulk RNA sequencing data from 888 medulloblastoma and 370 ependymoma tumors to establish a comprehensive reference landscape. Following rigorous batch effect correction, normalization, and dimensionality reduction, we constructed a unified landscape to explore gene e...

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Literature Corpus work: 120eeaad-3bc1-5a1e-907e-701d75fddde7
DOI: 10.1101/2024.10.21.619495

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