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Article

Oncogene aberrations drive medulloblastoma progression, not initiation

7 May 2025

Abstract excerpt

Abstract Despite recent advances in understanding disease biology, treatment of group 3/4 medulloblastoma remains a therapeutic challenge in paediatric neuro-oncology 1 . Bulk-omics approaches have identified considerable intertumoural heterogeneity in group 3/4 medulloblastoma, including the presence of clear single-gene oncogenic drivers in only a subset of cases, whereas in most cases, large-scale copy number...

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PMID: 40335697
DOI: 10.1038/s41586-025-08973-5

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