Article

<i>APOE4</i> poses opposite effects of plasma LDL on white matter integrity in older adults

2023-10-28

Abstract excerpt

<h4>INTRODUCTION</h4> APOE4 is a strong genetic risk factor of Alzheimer’s disease and is associated with changes in metabolism. However, the interactive relationship between APOE4 and plasma metabolites on the brain remains largely unknown. <h4>MEHODS</h4> In the UK Biobank, we investigated the moderation effects of APOE4 on the relationship between 249 plasma metabolites derived from nuclear magnetic resonance...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7f37ed34-d0bd-515e-b90c-50fa8b7b926f
DOI: 10.1101/2023.10.24.563796

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>APOE4</i> poses opposite effects of plasma LDL on white matter integrity in older adultsDOI 10.1101/2023.10.24.563796Read

A comprehensive analysis of <i>APOE</i> genotype effects on human brain structure in the UK BiobankSemantic proximity Read

Is there association between <i>APOE</i> e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)Semantic proximity Read

Interaction between <i>APOE4</i> status and lifestyle on brain and cognitive outcomes in cognitively unimpaired older adultsSemantic proximity Read

A comprehensive analysis of APOE genotype effects on human brain structure in the UK Biobank.Semantic proximity Read

Effects of APOE on brain white matter microstructure in healthy adults.Semantic proximity Read

Associations of<i>APOE</i>e2/e4 dosage and lifestyle on neuroimaging markers in the UK BiobankSemantic proximity Read

Exploration of Alzheimer’s Disease MRI Biomarkers Using <i>APOE4</i> Carrier Status in the UK BiobankSemantic proximity Read

White matter integrity and its association with amyloid-PET and serum NfL in healthy<i>APOE4</i>homozygotes, heterozygotes and non-carriesSemantic proximity Read

Effects of ApoE4 and ApoE2 genotypes on subcortical magnetic susceptibility and microstructure in 27,535 participants from the UK Biobank.Semantic proximity Read

APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies.Semantic proximity Read

The Interaction Effects of Age, APOE and Common Environmental Risk Factors on Human brain StructureSemantic proximity Read

Differences in AD-related pathology profiles across APOE groupsSemantic proximity Read