Article
Whole genome, whole population sequencing reveals that loss of signaling networks is the major adaptive strategy in a constant environment.
PLoS genetics - 1 Nov 2013
Kvitek Daniel J, Sherlock Gavin
Abstract excerpt
Molecular signaling networks are ubiquitous across life and likely evolved to allow organisms to sense and respond to environmental change in dynamic environments. Few examples exist regarding the dispensability of signaling networks, and it remains unclear whether they are an essential feature of a highly adapted biological system. Here, we show that signaling network function carries a fitness cost in yeast...
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