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Article

Molecular specificity, convergence and constraint shape adaptive evolution in nutrient-poor environments.

PLoS genetics - 1 Jan 2014

Hong Jungeui, Gresham David

Abstract excerpt

One of the central goals of evolutionary biology is to explain and predict the molecular basis of adaptive evolution. We studied the evolution of genetic networks in Saccharomyces cerevisiae (budding yeast) populations propagated for more than 200 generations in different nitrogen-limiting conditions. We find that rapid adaptive evolution in nitrogen-poor environments is dominated by the de novo generation and...

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PMID: 24415948
DOI: 10.1371/journal.pgen.1004041
PMCID: PMC3886903

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