Article

Mismatch-Assisted Toehold Exchange Cascades for Magnetic Nanoparticle-Based Nucleic Acid Diagnostics

2025-03-15

Abstract excerpt

<h4>ABSTRACT</h4> Sensitive, simple, and rapid detection of nucleic acid sequences at point-of-care (POC) settings is still an unmet quest. Magnetic readout assays combined with toehold-mediated strand displacement (TMSD)-based circuits are amplification- and wash-free, essential features for contributing to this demand. Nevertheless, nonenzymatic TMSD circuits are slow with low sensitivity for early disease diag...

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Literature Corpus work: 7f1b13b8-3d66-55fc-af99-5eecde14131b
DOI: 10.1101/2025.03.14.643268

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