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Engineering of a DNA/γPNA Hybrid Nanoreporter for ctDNA Mutation Detection via γPNA Urinalysis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Sept 2024

Xiang Zhichu, Lu Jianhua, Ming Yang, Guo Weisheng, Chen Xiaoyuan, Sun Weijian

Abstract excerpt

Detection of circulating tumor DNA (ctDNA) mutations, which are molecular biomarkers present in bodily fluids of cancer patients, can be applied for tumor diagnosis and prognosis monitoring. However, current profiling of ctDNA mutations relies primarily on polymerase chain reaction (PCR) and DNA sequencing and these techniques require preanalytical processing of blood samples, which are time-consuming, expensive,...

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Identifiers

PMID: 38958527
DOI: 10.1002/advs.202310225
PMCID: PMC11434236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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