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Hairpin-Mediated TMSDR-CHA Signal Conversion for Highly Specific Single-Base Discrimination of EGFR L858R Mutation.

Analytical chemistry - 2 Jun 2026

Gao Qingfeng, Cheng Yao, Zhou Kun, He Jingjing, Liu Yongmin, Wang Ci, Xie Guoming

Abstract excerpt

The detection of EGFR L858R mutations (a key driver of non-small-cell lung cancer (NSCLC)) has become critical for precision medicine, driven by rapid advancements in molecular diagnostics. Signal-converting nucleic acid technology simplifies assays and reduces costs in high-throughput screening, but suffers from insufficient single-base discrimination and severe nonspecific background signal─two long-standing...

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Identifiers

PMID: 42139191
DOI: 10.1021/acs.analchem.6c01906

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EGFR

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