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DNA Nanosieve-Based Regenerative Electrochemical Biosensor Utilizing Nucleic Acid Flexibility for Accurate Allele Typing in Clinical Samples.

ACS sensors - 26 Mar 2021

Chen Jin-Yuan, Yang Liang-Yong, Liu Zhou-Jie, Wei Qing-Xia, Zhang Ying, Wu Bing, Zhong Guang-Xian, Fu Leng-Xi, Lin Xin-Hua, Weng Xiu-Hua, Xu Xiong-Wei

Abstract excerpt

Herein, an interface-based DNA nanosieve that has the ability to differentiate ssDNA from dsDNA has been demonstrated for the first time. The DNA nanosieve could be readily built through thiol-DNA's self-assembly on the gold electrode surface, and its cavity size was tunable by varying the concentration of thiol-DNAs. Electrochemical chronocoulometry using [Ru(NH3)6]3+ as redox revealed that the average...

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PMID: 33657808
DOI: 10.1021/acssensors.0c02720

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