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DNAzyme-activated rolling circle amplification cascade nanomachine for sub-femtomolar detection of tuberculosis single-nucleotide mutation.

Analytica chimica acta - 1 Dec 2025

Sun Nan, Li Tingting, Yang Yulin, Chen Zhenhua, Gao Qian, Chen Haobin, Zhou Zheyuan, Tian Bo

Abstract excerpt

BACKGROUND: Tuberculosis (TB) remains a global health crisis, with drug-resistant strains posing significant diagnostic challenges due to the high cost and performance limitations of current methods. Rifampicin-resistant TB (RR-TB), approximately 97% of which are associated with rpoB 531T single-nucleotide mutation, presents a critical target for TB control. Padlock probe ligation-based rolling circle...

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PMID: 41093528
DOI: 10.1016/j.aca.2025.344666

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