Article

A spring-loaded and leakage-tolerant synthetic gene switch for in-vitro detection of DNA and RNA

2024-02-14

Abstract excerpt

<h4>ABSTRACT</h4> Nucleic acid tests (NATs) are essential for biomedical diagnostics. Traditional NATs, often complex and expensive, have prompted the exploration of Toehold-Mediated Strand Displacement (TMSD) circuits as an economical alternative. However, the wide application of TMSD-based reactions is limited by ‘leakage’—the spurious activation of the reaction leading to high background signals and false posi...

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Literature Corpus work: 547be205-9904-5a19-91d9-12cdba4b3116
DOI: 10.1101/2024.02.12.579921

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