Article

Inhibition of Asparagine Synthetase Effectively Retards Polycystic Kidney Disease Progression

2023-10-10

Abstract excerpt

Polycystic Kidney Disease (PKD) is a genetic disorder characterized by bilateral cyst formation. We showed that PKD cells and kidneys display metabolic alterations, including the Warburg effect and glutaminolysis, sustained in vitro by the enzyme asparagine synthetase (ASNS). Here, we used antisense oligonucleotides (ASO) against Asns in orthologous and slowly progressive PKD murine models and show that treatmen...

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Literature Corpus work: 7f0b43c3-fa47-5e7b-be6e-824b3a6d6257
DOI: 10.1101/2023.10.10.561720

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