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Article

Metabolic reprogramming in a slowly developing orthologous model of polycystic kidney disease.

American journal of physiology. Renal physiology - 1 Mar 2022

Hopp Katharina, Kleczko Emily K, Gitomer Berenice Y, Chonchol Michel, Klawitter Jost, Christians Uwe, Klawitter Jelena

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease and affects 1 in 1,000 individuals. There is accumulating evidence suggesting that there are shared cellular mechanisms responsible for cystogenesis in human and murine PKD and that reprogramming of metabolism is a key disease feature. In this study, we used a targeted metabolomics approach in an orthologous mouse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35037466
DOI: 10.1152/ajprenal.00262.2021
PMCID: PMC8858679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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