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Article

Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis

30 Jun 2018

Abstract excerpt

Defects in basal autophagy limit the nutrient supply from recycling of intracellular constituents. Despite our understanding of the prosurvival role of macroautophagy/autophagy, how nutrient deprivation, caused by compromised autophagy, affects oncogenic KRAS-driven tumor progression is poorly understood. Here, we demonstrate that conditional impairment of the autophagy gene Atg5 (atg5-KO) extends the survival of...

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PMID: 29956571
DOI: 10.1080/15548627.2018.1450708

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