Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Editor's cut: DNA cleavage by CRISPR RNA-guided nucleases Cas9 and Cas12a

24 Dec 2019

Abstract excerpt

Discovered as an adaptive immune system of prokaryotes, CRISPR-Cas provides many promising applications. DNA-cleaving Cas enzymes like Cas9 and Cas12a, are of great interest for genome editing. The specificity of these DNA nucleases is determined by RNA guides, providing great targeting adaptability. Besides this general method of programmable DNA cleavage, these nucleases have different biochemical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Cytomegalovirus and herpesvirus research
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31872209
DOI: 10.1042/bst20190563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Editor's cut: DNA cleavage by CRISPR RNA-guided nucleases Cas9 and Cas12aPMID 31872209Read ↗

Disruptive Technology: CRISPR/Cas-Based Tools and ApproachesSemantic proximity Read ↗

Application of CRISPR/Cas9 for biomedical discoveriesSemantic proximity Read ↗

Development and Application of CRISPR-Cas Based ToolsSemantic proximity Read ↗

Structural principles of CRISPR-Cas enzymes used in nucleic acid detectionSemantic proximity Read ↗

Harnessing noncanonical trans-cleavage characteristics of Cas12 and Cas13a to enhance CRISPR-based diagnosticsSemantic proximity Read ↗

The rapidly advancing Class 2 CRISPR‐Cas technologies: A customizable toolbox for molecular manipulationsSemantic proximity Read ↗

Advances in application of CRISPR-Cas13a systemSemantic proximity Read ↗

Discovery of Diverse CRISPR-Cas Systems and Expansion of the Genome Engineering ToolboxSemantic proximity Read ↗

CRISPR-Cas Systems: Programmable Nuclease Revolutionizing the Molecular DiagnosisSemantic proximity Read ↗

CRISPR/CAS Genome Editing Technology: Implications And ChallengesSemantic proximity Read ↗

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future InnovationsSemantic proximity Read ↗

A naturally DNase-free CRISPR-Cas12c enzyme silences gene expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.