Article
PlmCas12e (CasX2) cleavage of CCR5: impact of guide RNA spacer length and PAM sequence on cleavage activity.
RNA biology - 1 Jan 2023
Armstrong David A, Hudson Taylor R, Hodge Christine A, Hampton Thomas H, Howell Alexandra L, Hayden Matthew S
Abstract excerpt
Gene editing using CRISPR/Cas (clustered regularly interspaced palindromic repeats/CRISPR-associated) is under development as a therapeutic tool for the modification of genes in eukaryotic cells. While much effort has focused on CRISPR/Cas9 systems from Streptococcus pyogenes and Staphylococcus aureus, alternative CRISPR systems have been identified from non-pathogenic microbes, including previously unknown class...
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