Article

Integrative transcriptomic analysis identifies a stromal–SPP1 macrophage– androgen receptor remodeling state associated with aggressive and treatment- refractory prostate cancer

2026-08-06

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Progression to aggressive and treatment-refractory prostate cancer is commonly attributed to tumor-cell-intrinsic androgen receptor (AR) reprogramming and lineage plasticity. However, whether these epithelial changes are coordinated with stromal remodeling and SPP1-expressing tumor-associated macrophage states remains incompletely understood. <bold>Methods</b...

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Literature Corpus work: 7ec70168-d8c4-5c78-a313-e912ca2a07cf
DOI: 10.21203/rs.3.rs-10122771/v1

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