Article

Human Prostate Cancer-Associated Macrophage Subtypes with Prognostic Potential Revealed by Single-cell Transcriptomics

2020-06-20

Abstract excerpt

<h4>ABSTRACT</h4> Macrophages in the tumor microenvironment are causally linked with prostate cancer development and progression, yet little is known about their composition in neoplastic human tissue. By performing single cell transcriptomic analysis of human prostate cancer resident macrophages, three distinct populations were identified in the diseased prostate. Unexpectedly, macrophages isolated from the tumo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bfd53b36-4c2b-51cf-bf27-6a453f4ebd29
DOI: 10.1101/2020.06.19.160770

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human Prostate Cancer-Associated Macrophage Subtypes with Prognostic Potential Revealed by Single-cell TranscriptomicsDOI 10.1101/2020.06.19.160770Read

The Prognostic Potential of Human Prostate Cancer-Associated Macrophage Subtypes as Revealed by Single-Cell TranscriptomicsSemantic proximity Read

Integrated analysis of single‑cell and bulk RNA‑sequencing identifies a signature based on macrophage marker genes involved in prostate cancer prognosis and treatment responsivenessSemantic proximity Read

Tumor Immune Microenvironment Clusters in Localized Prostate Adenocarcinoma: Prognostic Impact of Macrophage Enriched/Plasma Cell Non-enriched SubtypesSemantic proximity Read

Multi-omics analysis reveals a macrophage-related marker gene signature for prognostic prediction, immune landscape, genomic heterogeneity, and drug choices in prostate cancerSemantic proximity Read

Dissection of prostate tumour, stroma and immune transcriptional components reveals a key contribution of the microenvironment for disease progressionSemantic proximity Read

Single-Cell Proteomics Defines the Cellular Heterogeneity of Localized Prostate CancerSemantic proximity Read

Single-cell proteomics defines the cellular heterogeneity of localized prostate cancerSemantic proximity Read

Spatial whole transcriptome profiling of primary tumor from patients with metastatic prostate cancerSemantic proximity Read

A tumor-associated macrophages related model for predicting biochemical recurrence and tumor immune environment in prostate cancer.Semantic proximity Read

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironmentSemantic proximity Read

Subversion of infiltrating prostate macrophages to a mixed immunosuppressive tumor-associated macrophage phenotype.Semantic proximity Read

Resolving the immune landscape of human prostate at a single-cell level in health and cancerSemantic proximity Read