Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homeodomain revisited: a lesson from disease-causing mutations.

Human genetics - 1 May 2005

Chi Young-In

Abstract excerpt

The homeodomain is a highly conserved DNA-binding motif that is found in numerous transcription factors throughout a large variety of species from yeast to humans. These gene-specific transcription factors play critical roles in development and adult homeostasis, and therefore, any germline mutations associated with these proteins can lead to a number of congenital abnormalities. Although much has been revealed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Conserved Sequence
Share to Genetic Diseases, Inborn

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Models, Molecular

Share to Molecular Sequence Data

Share to Mutation

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 15726414
DOI: 10.1007/s00439-004-1252-1
PMCID: PMC1579204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homeodomain revisited: a lesson from disease-causing mutations.PMID 15726414Read ↗

The Homeodomain Resource: 2003 update.Semantic proximity Read ↗

The Homeodomain Resource: sequences, structures and genomic information.Semantic proximity Read ↗

DNA binding analysis of rare variants in homeodomains reveals homeodomain specificity-determining residues.Semantic proximity Read ↗

DNA binding analysis of rare variants in homeodomains reveals novel homeodomain specificity-determining residuesSemantic proximity Read ↗

Homeobox genes and human genetic disorders.Semantic proximity Read ↗

Molecular evolution of the homeodomain family of transcription factors.Semantic proximity Read ↗

Constraint and conservation of paired-type homeodomains predicts the clinical outcome of missense variants of uncertain significance.Semantic proximity Read ↗

Identification and in vivo functional investigation of a HOMER2 nonstop variant causing hearing loss.Semantic proximity Read ↗

The Participation of the Intrinsically Disordered Regions of the bHLH-PAS Transcription Factors in Disease DevelopmentSemantic proximity Read ↗

Decoding the mechanisms of cooperative DNA binding by the Paired-like homeodomain familySemantic proximity Read ↗

Crystal structure of an ancient protein: evolution by conformational epistasis.Semantic proximity Read ↗

Analysis of the structure and function of the transcriptional coregulator HOP.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.