Article
NAT8L (N-acetyltransferase 8-like) accelerates lipid turnover and increases energy expenditure in brown adipocytes.
The Journal of biological chemistry - 13 Dec 2013
Pessentheiner Ariane R, Pelzmann Helmut J, Walenta Evelyn, Schweiger Martina, Groschner Lukas N, Graier Wolfgang F, Kolb Dagmar, Uno Kyosuke, Miyazaki Toh, Nitta Atsumi, Rieder Dietmar, Prokesch Andreas, Bogner-Strauss Juliane G
Abstract excerpt
NAT8L (N-acetyltransferase 8-like) catalyzes the formation of N-acetylaspartate (NAA) from acetyl-CoA and aspartate. In the brain, NAA delivers the acetate moiety for synthesis of acetyl-CoA that is further used for fatty acid generation. However, its function in other tissues remained elusive. Here, we show for the first time that Nat8l is highly expressed in adipose tissues and murine and human adipogenic cell...
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