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ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation

28 Feb 2025

Abstract excerpt

Senescence-associated secretory phenotype (SASP) mediates the biological effects of senescent cells on the tissue microenvironment and contributes to ageing-associated disease progression. ACSS2 produces acetyl-CoA from acetate and epigenetically controls gene expression through histone acetylation under various circumstances. However, whether and how ACSS2 regulates cellular senescence remains unclear. Here, we...

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PMID: 40021646
DOI: 10.1038/s41467-025-57334-3

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