Article

The Protein Acetylation Rheostat: Linking Autophagy and Senescence in Metabolic Disease

2026-07-03

Abstract excerpt

Metabolic diseases, such as obesity, type 2 diabetes (T2DM), and metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD), emerge from chronic nutrient overload that progressively disrupts cellular homeostasis and precipitates persistent inflammatory remodeling. Two stress-adaptive programs sit at the center of such pathological transition: autophagy, the homeostatic engine responsible for...

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Literature Corpus work: 5d369907-b58f-530e-a4d8-2b9bcc48412d
DOI: 10.20944/preprints202607.0186.v1

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