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Article

N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes.

Scientific reports - 5 Apr 2016

Prokesch A, Pelzmann H J, Pessentheiner A R, Huber K, Madreiter-Sokolowski C T, Drougard A, Schittmayer M, Kolb D, Magnes C, Trausinger G, Graier W F, Birner-Gruenberger R, Pospisilik J A, Bogner-Strauss J G

Abstract excerpt

Histone acetylation depends on the abundance of nucleo-cytoplasmic acetyl-CoA. Here, we present a novel route for cytoplasmic acetyl-CoA production in brown adipocytes. N-acetylaspartate (NAA) is a highly abundant brain metabolite catabolized by aspartoacylase yielding aspartate and acetate. The...

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Identifiers

PMID: 27045997
DOI: 10.1038/srep23723
PMCID: PMC4820693

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-27045997-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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