Article

<i>BrainGENIE</i> : The Brain Gene Expression and Network Imputation Engine

2020-10-27

Abstract excerpt

In vivo experimental analysis of human brain tissue poses substantial challenges and ethical concerns. We developed a novel method called the Brain Gene Expression and Network Imputation Engine ( BrainGENIE ) that uses peripheral-blood transcriptomes to predict brain-tissue-specific gene-expression levels. BrainGENIE reliably predicted brain-tissue-specific expression levels for 1,733 – 11,569 genes (false-disco...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e9fa8f7-4160-5686-91d6-a31ca01406ab
DOI: 10.1101/2020.10.27.356766

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>BrainGENIE</i> : The Brain Gene Expression and Network Imputation EngineDOI 10.1101/2020.10.27.356766Read

BrainGENIE: The Brain Gene Expression and Network Imputation Engine.Semantic proximity Read

<i>recount-brain</i> : a curated repository of human brain RNA-seq datasets metadataSemantic proximity Read

Gene expression imputation and cell-type deconvolution in human brain with spatiotemporal precision and its implications for brain-related disorders.Semantic proximity Read

Single-nucleus transcriptome-wide association study of human brain disordersSemantic proximity Read

Deep learning-based brain transcriptomic signatures associated with the neuropathological and clinical severity of Alzheimer’s diseaseSemantic proximity Read

A transcriptomic atlas of the human brain reveals genetically determined aspects of neuropsychiatric health.Semantic proximity Read

Inference of Cell Type Composition from Human Brain Transcriptomic Datasets Illuminates the Effects of Age, Manner of Death, Dissection, and Psychiatric DiagnosisSemantic proximity Read

Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases.Semantic proximity Read

Comprehensive evaluation of deconvolution methods for human brain gene expressionSemantic proximity Read

A systematic survey of human tissue-specific gene expression and splicing reveals new opportunities for therapeutic target identification and evaluationSemantic proximity Read

Characterising processing conditions that artifactually bias human brain tissue transcriptomesSemantic proximity Read

The Human Brainome: changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer’s diseaseSemantic proximity Read