Article
Gene expression imputation and cell-type deconvolution in human brain with spatiotemporal precision and its implications for brain-related disorders.
Genome research - 1 Jan 2021
Pei Guangsheng, Wang Yin-Ying, Simon Lukas M, Dai Yulin, Zhao Zhongming, Jia Peilin
Abstract excerpt
As the most complex organ of the human body, the brain is composed of diverse regions, each consisting of distinct cell types and their respective cellular interactions. Human brain development involves a finely tuned cascade of interactive events. These include spatiotemporal gene expression changes and dynamic alterations in cell-type composition. However, our understanding of this process is still largely...
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