Deep learning-based brain transcriptomic signatures associated with the neuropathological and clinical severity of Alzheimer’s disease

Abstract excerpt

Abstract Brain tissue gene expression from donors with and without Alzheimer’s disease has been used to help inform the molecular changes associated with the development and potential treatment of this disorder. Here, we use a deep learning method to analyse RNA-seq data from 1114 brain donors from the Accelerating Medicines Project for Alzheimer’s Disease consortium to characterize post-mortem brain...

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