Article
BrainGENIE: The Brain Gene Expression and Network Imputation Engine.
Translational psychiatry - 22 Mar 2023
Hess Jonathan L, Quinn Thomas P, Zhang Chunling, Hearn Gentry C, Chen Samuel, Kong Sek Won, Cairns Murray, Tsuang Ming T, Faraone Stephen V, Glatt Stephen J
Abstract excerpt
In vivo experimental analysis of human brain tissue poses substantial challenges and ethical concerns. To address this problem, we developed a computational method called the Brain Gene Expression and Network-Imputation Engine (BrainGENIE) that leverages peripheral-blood transcriptomes to predict brain tissue-specific gene-expression levels. Paired blood-brain transcriptomic data collected by the Genotype-Tissue...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.