Article

The Human Brainome: changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer’s disease

2023-12-14

Abstract excerpt

<title>Abstract</title> <p>While there are currently over 40 replicated genes with mapped risk alleles for Late Onset Alzheimer’s disease (LOAD), the <italic>Apolipoprotein</italic> E locus E4 haplotype is still the biggest driver of risk, with odds ratios for neuropathologically confirmed E44 carriers exceeding 30 (95% confidence interval 16.59–58.75). We sought to address whether the <italic>APOE</italic> E4 ha...

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Literature Corpus work: 7c1eb4bd-0191-57d9-9f79-06e387e5dae2
DOI: 10.21203/rs.3.rs-3678057/v1

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