Article

MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity

2024-07-08

Abstract excerpt

Lewy pathology, consisting of Lewy bodies and Lewy neurites, is the pathological hallmark of synucle-inopathies such as Parkinson’s disease and dementia with Lewy bodies, but it is generally thought to represent late-stage pathological changes. In contrast, α-synuclein oligomers are regarded as early-stage pathology, likely involved in disease progression and cellular toxicity. Oligomers, however, are not de-tecte...

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Literature Corpus work: 7e8911bc-1aea-5048-9805-e382a65045bb
DOI: 10.1101/2024.07.08.602186

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