Article

Abundant non-inclusion α-synuclein pathology in Lewy body-negative LRRK2-mutant cases

2024-12-20

Abstract excerpt

Lewy body diseases are common neurodegenerative diseases, including Parkinson’s disease (PD) and dementia with Lewy bodies, which lead to both motor and non-motor symptoms. They are neuropathologically characterized by loss of neuromelanized neurons in the substantia nigra pars compacta and α-synuclein-immunopositive inclusions (Lewy bodies) in several types of neurons in the brain. A fraction of monogenic PD case...

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Literature Corpus work: 240f7169-b837-5eca-aa29-3eaafb1dc5ea
DOI: 10.1101/2024.12.20.629583

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