Article

Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies

2021-10-21

Abstract excerpt

Dementia with Lewy bodies is pathologically defined by the cytoplasmic accumulation of alpha-synuclein within neuronal cells in the brain. Alpha-synuclein is predominately pre-synaptic, but has been reported present in various subcellular compartments in cell and animal models. In particular, nuclear alpha-synuclein is evident in-vitro and in disease models and has been associated with altered DNA integrity, gene...

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Literature Corpus work: 7e2796d1-9f72-57cd-b122-9bbf8eb757b7
DOI: 10.1101/2021.10.20.465125

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