Article

Widespread Distribution of α-Synuclein Oligomers in <i>LRRK2</i> -related Parkinson’s Disease

2024-12-20

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 ( LRRK2 ) are the most common cause of familial and sporadic Parkinson’s disease (PD). While the clinical features of LRRK2 -PD patients resemble those of typical PD, there are significant differences in the pathological findings. The pathological hallmark of definite PD is the presence of α-synuclein (αSYN)-positive Lewy-related pathology; however, approximately half of...

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Literature Corpus work: 390979d0-09ef-5dbf-ac0e-c878684d4d55
DOI: 10.1101/2024.12.18.629265

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