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Article

Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue

2024-02-19

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative condition characterised by the presence in the brain of large intraneuronal aggregates, known as Lewy bodies and Lewy neurites, containing fibrillar α-synuclein. According to the amyloid hypothesis, these large end-stage species form from smaller soluble protein assemblies, often termed oligomers, which are proposed as early drivers of pathogenesis. To date, h...

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Literature Corpus work
265686d2-7936-5b0a-a96d-5c0feb4ef4dd
DOI
10.1101/2024.02.17.580698
Open publication

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Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissueDOI 10.1101/2024.02.17.580698
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