Article

Foundation model reveals the shared organization of transcription and topologically associating domains

2025-04-02

Abstract excerpt

<h4>Summary</h4> The three-dimensional organization of chromatin into topologically associating domains (TADs) may impact gene regulation by bringing distant genes into contact. However, studies of TADs’ function and their influence on transcription have been constrained by ambiguities in TAD boundary definitions and challenges in directly measuring their regulatory effects. We overcome these limitations by devel...

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Literature Corpus work: 7e88dbcf-0ce8-5e2b-9b83-086e7d912e7a
DOI: 10.1101/2025.03.31.646349

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