Article

Modular Combinatorial Binding among Human <i>Trans</i> -acting Factors Reveals Direct and Indirect Factor Binding

2015-09-30

Abstract excerpt

The combinatorial binding of trans -acting factors (TFs) to regulatory genomic regions is an important basis for the spatial and temporal specificity of gene regulation. We present a new computational approach that reveals how TFs are organized into combinatorial regulatory programs. We define a regulatory program to be a set of TFs that bind together at a regulatory region. Unlike other approaches to characteriz...

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Literature Corpus work: a34cb632-25d6-5eed-8156-eb608986ac1c
DOI: 10.1101/027953

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