Article

Aβ-induced distress of astrocytes triggers Alzheimer disease pathology through non-canonical δ secretase activity

2025-01-31

Abstract excerpt

<h4>ABSTRACT</h4> The importance of astrocytes for Alzheimer disease (AD) pathology is increasingly appreciated, yet the mechanisms whereby this cell type impacts neurodegenerative processes remain elusive. In a genetic mouse model with diminished astrocyte stress response, even low levels of amyloid-β trigger astrocyte reactivity, resulting in brain inflammation and massive amyloid and tau pathologies. This dysf...

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Literature Corpus work: 4f6b30e8-7981-5ae9-a514-a89ae8b5414d
DOI: 10.1101/2025.01.30.635618

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